Vol. 6, Issue 1, Part A (2024)

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation, leading to joint destruction and systemic manifestations. The immunopathological mechanisms underlying RA are complex, involving a dysregulated immune response that targets self-antigens in the synovial tissue. This review provides a detailed examination of the immunopathological findings in RA, focusing on the roles of various immune cells, cytokines, autoantibodies, and genetic factors. The review also explores recent advancements in understanding the molecular pathways involved in RA pathogenesis, highlighting potential therapeutic targets and the implications for personalized medicine.