Vol. 6, Issue 1, Part A (2024)

Colorectal cancer (CRC) is one of the most prevalent and deadly malignancies worldwide. Histopathological examination plays a crucial role in diagnosing CRC, staging the disease, and guiding treatment strategies. Variability in histopathological features can significantly impact the prognosis of CRC patients, influencing clinical outcomes and treatment responses. This review article provides a comprehensive analysis of the histopathological variability in CRC and its implications for prognosis. We explore the major histopathological characteristics of CRC, including tumor grade, histological type, and molecular subtypes, and discuss how these factors contribute to prognosis and clinical decision-making.